The effect of ethanol extract of Andaliman (Zanthoxylum acanthopodium DC.) on kidney damage in tartrazine-induced rats

Tartrazine is a yellow synthetic dye with aromatic and chromo groups. It widely used in food colouring products cosmetics, prolonged consumption can cause kidney damage. Andaliman (Zanthoxylum acanthopodium DC.) North Sumatra-native spice plant which reported as antioxidant to repair This study was conducted determine the effect of ethanol extract andaliman fruit on morphology, ureum levels, histology, glomerular diameter tartrazine-induced rats. employed completely randomised design (CRD). The dissolved CMC-Na 1%. Twenty-five rats were divided into 5 groups: negative control (KN), positive (tartrazine indcution/PN), treated groups (P1, P2, P3 induced tartazine at dose 150 mg/kg BW, 300 450 respectively). After 30 days treatment, damage observed based colour surface kidneys, index, level, score, diameter. There are no significant different index among (p > 0.05). Tartrazin 15 BW able induce indicated by increase decrease control. treatment tartazine-induced level score incread